Groupe de Recherche et d'Etudes du Processus Inflammatoire
ABOUT US
Le thème principal de recherche du GREPI depuis de nombreuses années est orienté vers l’inflammation médiée par la production de dérivés réactifs de l’oxygène avec
1. les mécanismes activateurs, fonctionnels et structuraux des NADPH oxydases, (les NOX)
2. la mise en jeu de la phase contact et du complément au niveau des tissus inflammatoires (endothélium).
3.La mise en évidence et étude de biomarqueurs dans les pathologies chroniques.
Ces questions contribuent à la compréhension du stress cellulaire à l’origine de pathologies humaines.
L’équipe développe ses projets dans la proximité des praticiens et des patients. Cette localisation offre l’opportunité d’investiguer sur les modèles humains appropriés et ouvre la possibilité de disposer d’échantillonnage pathologiques bien identifiés.
RESEARCH INTERESTS
Kinin activation and catabolism: entities for angioedema
Kinins are released locally from their parental molecules, the kininogens, as a result of limited proteolysis by Serine proteases called kallikreins
Complement in adaptive immunity
Complement is firmly established as instructor of adaptive immunity and is required for germinal centre formation, Ab responses and normal B cell memory development. We provided an illustration demonstrating that a C3-/- patient exhibits a memory B cell defect, with impaired vaccine Ab production
NADPH oxidases (Nox)
ROS became a very important goal and a very dynamic research field. This interest relates to the recognized roles of ROS as critical mediators in variety of physiological functions and processes e.g. host defence, inflammation, hormone biosynthesis, cell proliferation, migration and differentiation, gene expression and signal transduction.
Rheumatoid diseases
Osteoarthritis :Several evidence support the involvement of kinins in the pathophysiology of OA: (1) kinin B2R have been detected in synovial tissue of OA patients
Rheumatoid Arthritis (RA): Together with the basic research on Nox2 activation, we investigate the impact of ROS produced by neutrophil Nox2 on inflammatory disorders, especially in the RA, one of the most common autoimmune diseases
Spondyloarthritis : Spondyloarthritis (SpA) pathogenesis involves environmental factors such as infections (C. trachomatis in reactive arthritis)
Rett syndrome : Rett syndrome (RTT) is a severe X-linked autism spectrum disorder caused by a dysfunction of a transcriptional factor methyl-CpG binding protein 2 (MeCP2) that strikes randomly one to 10,000 girls in their early childhood when males instead died in utero
Transfusion and transplantation
This issue is entering in the field of the GREPI know-how with the inflammatory parameters developed during the transfusion adverse reactions. It will take advantage of the expertise of neutrophil, endothelial cells, complement and kinins. A program dedicated to TRALI etiopathogenesis has been launched (2012), a starting point of investigation interests of GREPI in transfusion.
