Impact of ROS
Pertaining with the Nox-specific inhibition of VE-cadherin disruption (and subsequent cell permeability), ROS production by neutrophil has been demonstrated to be critical in the regulation of endothelial permeability (Khoy K, Nguyen MVC, ms in progress). The question is next addressed whether ligand primes the activation of cell partners between circulating phagocytic cells and the endotheli
l monolayer.